It is reported, that Lin28a/b-mRNAs are suppressed by microRNA mir-125/lin-4 during stem cell differentiation46, that pluripotent factors transcriptionally upregulate Lin28a in mammalian ESCs47, and that Myc or NF-kB can transcriptionally activate Lin28b in cancer cells45,48,49. This evidence concerns the gene LIN28B and cancer.