It is reported, that Lin28a/b-mRNAs are suppressed by microRNA mir-125/lin-4 during stem cell differentiation46, that pluripotent factors transcriptionally upregulate Lin28a in mammalian ESCs47, and that Myc or NF-kB can transcriptionally activate Lin28b in cancer cells45,48,49. The gene discussed is LIN28A; the disease is cancer.