Table 1 showed the results of IHC staining of CXCR3 protein. Of 156 GC samples, 59 (37.82%) showed high expression of CXCR3 protein and 97 (62.18%) showed low expression. In paracancerous tissues, 26 (16.67%) showed high expression of CXCR3 protein, and 130 (83.33%) showed low expression. The chi-square test showed that level of CXCR3 was significantly increased in GC tissues (P < 0.001). This evidence concerns the gene CXCR3 and gastric cancer.