Our data also elucidated that high expression of CXCR3 protein correlated with less M2 macrophages infiltration and independently associated with better OS in GC patients, suggesting that CXCR3 may be associated with the infiltration of several types of immune cells in the immune microenvironment of GC, especially with M2 macrophages. This evidence concerns the gene CXCR3 and gastric cancer.