Subcutaneous vaccination of CpG-ODN 2006 with glioma cell lysate (cell line GL261) in glioma-bearing mice had a potent antitumoral effect with a cure rate of 55%; the mice showed a significant increase in activated DCs and a considerable expansion of T lymphocytes, which produced IFN-γ and lysed glioma cells. Here, IFNG is linked to central nervous system cancer.