TLR2 and central nervous system cancer: Microglia, astrocytes, and neuroblastoma cells treated with LTA and Pam3CSK4, two TLR2 ligands, induced tyrosine phosphorylation of STAT1 in both astrocytes and microglia, but it was not detected in neuroblastoma or different glioma cell lines (GL26, U87, and U373) [56].