FMO3 and trimethylaminuria: The variants c.913G>T;p.(Glu 305*) and c.458C>T;p.(Pro153Leu) in this Irish population with severe TMAU is consistent with our earlier observations in Australian and North American families of Irish and British descent.22, 23 In addition to these two more commonly described FMO3 variants and common polymorphisms other variants identified in cohort appear to be “private” variants as described in other populations.