G6PD and acute myeloid leukemia: Glycolysis is an important part of the energy metabolism in malignant cells,29 and differences in glycolysis appear to be important for in vivo chemosensitivity in AML.28 We investigated the antiproliferative effects of three inhibitors directed against molecular targets that are relevant to glycolysis: (i) hexokinase, which is the rate-limiting enzyme in glycolysis; (ii) the lactate transporter Monocarboxylate Transporter 1 (MCT-1); and (iii) the rate-limiting enzyme in the pentose phosphate pathway (a parallel pathway to glycolysis), glucose-6-phosphate dehydrogenase (G6PD).