Therefore, we hypothesized that the utilization of nanoparticles with specific ligand would alter the function of breast cancer cells (e.g., uptake capacity or downregulation of membrane-bound TNF) and mediate TNF-TNFR2 signal that leads to distinct immunological effects, such as expansion of breast cancer cells, cytokines secretion, or survival capacity (Figure 6). This evidence concerns the gene TNF and breast carcinoma.