TNFRSF1B and breast carcinoma: They reported that the expression levels of TNFR2 in breast cancer cells were positively associated with doxorubicin (anthracycline type of chemotherapy) resistance; overexpression of TNFR2 significantly promoted doxorubicin resistance, while less expression of TNFR2 significantly dampened doxorubicin resistance, while in turn this regulated the DNA damage and repair PARP protein [95].