Dormant tumour cells compete with HSCs for bone marrow engraftment and lodge close to the endosteal niche made up by N-cadherin-positive osteoblasts, also known as SNOs.9 In this neighbourhood, they stay adjacent to the surface N-cadherin-expressing SNOs, likely by a homophilic interaction with their own N-cadherin and remain cell cycle arrested thanks to the Notch2 pathway. This evidence concerns the gene NOTCH2 and neoplasm.