NOTCH2 and breast cancer: It is important to acknowledge that, for this aspect, mouse models do not completely recapitulate the human disease, because in contrast with luminal-like cancers, basal-like breast cancers are rarely reported to give bone metastasis in patients.48 This inconsistency is further suggested by the observation that high Notch2 expression in human primary breast cancers was associated with improved overall survival both in oestrogen receptor-positive and -negative breast cancer patients.