ACE and type 2 diabetes mellitus: In another study, the DBP/SBP was reduced by a mean (95% CI) of 7 (2, 12)/3 (1–6) mmHg with spironolactone 25–50 mg/day (n = 29) vs a placebo (n = 30) in patients with type 2 diabetes and macroalbuminuria receiving long-term treatment with an ACE inhibitor or ARB [27].