AGER and acute respiratory distress syndrome: Two-way repeated measures analyses of variance (ANOVA) indicated a group effect (P = 0.001), a time effect (P = 0.03) and a significant interaction (P < 10−4) with a detrimental effect of HCl-induced ARDS on the course of arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO2), when compared with the absence of ARDS or with the use of an anti-RAGE therapy with either RAP or sRAGE in animals with ARDS (Fig. 2).