AGER and acute respiratory distress syndrome: Third, we were unable to test additional means of inhibiting RAGE, such as with FPS-ZM1 (a high-affinity specific blocker that inhibits ligand binding to RAGE that was not used in this study for financial reasons)44, or multiple routes of administration, doses and timings for treatment with RAP and sRAGE, and whether a RAGE inhibition strategy may reduce lung injury and improve AFC when applied after experimental ARDS is established remains unknown.