However, it was up-regulated in six of the tested cell lines, particularly in Mel624 (BRAF mutation, Human) and B16F10 (BRAF wild-type, Mouse) cells, two aggressive model melanoma cell lines, as well as WM115 (BRAF mutation, Human), WM793 (BRAF mutation, Human), WM3670 (BRAF and NRAS mutation, Human), and CHL-1 (BRAF and NRAS wild-type, Human) (Fig. 1c). Here, NRAS is linked to melanoma.