GPT and Cirrhosis: HBsAg levels have also been used to classify individuals into those with inactive carriage (HBV DNA levels of <2,000 IU/ml and normal alanine aminotransferase [ALT] levels [14, 15]) versus those with active CHB (with higher viral loads and elevated risks of inflammatory liver disease, fibrosis, and cirrhosis [16, –, 19]).