No potential variants were found in 18 other genes (BMP1, COL1A2, CREB3L1, CRTAP, FKBP10, IFITM5, MBTPS2, P3H1, P4HB, PLOD2, PLS3, PPIB, SERPINF1, SERPINH1, SPARC, TMEM38B, WNT1, and SEC24D) associated with OI or in 10 other genes (ADAMTS2, B3GALT6, B4GALT7, COL3A1, COL5A2, DSE, FKBP14, PLOD1, PLOD3, and TNXB) associated with EDS. The gene discussed is CREB3L1; the disease is Ehlers-Danlos syndrome.