Like other proteins of the FET family (FUS, EWSR1 and TAF15; Ewing’s sarcoma (EWS) and TAF15 (TATA-binding protein-associated factor), mutations in fused in sarcoma (FUS) are directly linked with protein aggregation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia patients. This evidence concerns the gene TAF15 and Ewing sarcoma.