Furthermore, the multivariate Cox’s analysis, which included age, sex, T stage, N stage, CEA level, tumor location, tumor size, histological type, therapeutic method, schistosomiasis history, and chitinase activity (dichotomized by the ROC curve), revealed that chitinase activity, but not CEA level, was an independent prognosis of metastasis in patients with CRC. The gene discussed is CEACAM5; the disease is colorectal carcinoma.