Along with V180I mutations in PRNP, genetic variations in other genes, such as lipoprotein(a) (LPA), Leucine-rich repeat kinase 2 (LRRK2), and fibroblast growth factor 20 (FGF20), which are directly or indirectly related to neurodegenerative diseases, were also observed in patients with V180I gCJD [16]. The gene discussed is PRNP; the disease is neurodegenerative disease.