ARID1A (missense) mutations are found in patients with colon cancer [52,53,54], and ARID1A loss promotes invasive adenocarcinoma via SWI/SNF-dependent gene expression regulation in vivo [55] or proliferation/5-fluorouracil (5-FU) resistance in vitro [56]. This evidence concerns the gene ARID1A and malignant colon neoplasm.