ARID1A and familial pancreatic carcinoma: Furthermore, Kimura et al. used a pancreatic cancer mouse model Ptf1a-Cre; KrasG12D to show that the loss of ARID1A expression promotes tumorigenesis—from PanIN to ductal adenocarcinoma (PDAC)—and enhances intraductal papillary mucinous neoplasm (IPMN) formation from the duct cell.