Regulators including euchromatic histone lysine methyltransferase 2 (EHMT2; G9a) that target H3K9 and H3K27, affect pancreatic cancer sensitivity toward gemcitabine via autocrine IL-8/CXCR1/2 stimulation in vitro [79], and further enhance mesenchymal transition by increasing polycomb repressive complex 2 (PRC2) recruitment, while decreasing the lysine demethylase 7A (KDM7A)’s expression to influence H3K27 methylation on E-cadherin promoter in vitro [80]. This evidence concerns the gene EHMT2 and familial pancreatic carcinoma.