MIR124-1HG and atherosclerosis: Indeed, RNCR3 has been found to be upregulated in human and mouse atherosclerotic plaques; its knock-down in ApoE−/− mice and after high-fat diet increases atherosclerosis, cholesterol and triglycerides plasma levels and the release of inflammatory mediators, indicating an anti-atherosclerotic role of RNCR3 [85].