SHH and retinopathy of prematurity: In addition, Shh and Ptch1 are overexpressed in the eye both in retinopathy of prematurity (ROP) [47] and in laser-induced choroidal neovascularization [47,104], promoting pathological angiogenesis; inhibition of the Hh pathway (Cyclopamine) results in reduced angiogenesis and decreased Vegfa and Ptch1 levels, placing Shh activation upstream of Vegfa in experimental retinal angiogenesis [47].