KDM6A and diffuse intrinsic pontine glioma: In an experimental model of diffuse intrinsic pontine glioma (DIPG), an invariably lethal childhood glioma [46], it has been shown that treatment with GSK J4, a potent and selective inhibitor of KDM6A/B, reverts the biological effect of K27M mutation and results in the dramatic improvement of survival in DIPG xenografted mice [45,47].