To verify this assumption, we performed GO analysis of EGR1‐bound and up‐regulated genes with DAVID.17 We did find that some up‐regulated genes were enriched in GO terms positive regulation of apoptotic process (Figure 4D), including ABR, ING2, CYP1B1, HIP1R, KLF11, VAV2, TGFB1, BCL2L11, and DUSP6. These results suggest that EGR1 activates the apoptosis‐related genes in YYJD‐treated lung cancer cells. This evidence concerns the gene HIP1R and lung cancer.