It can be induced by a wide range of extracellular stimuli (including growth factors and cytokines) and activates the downstream target genes through the consensus GC‐rich sequence 5’‐ MCGCCCACDC‐3’0.36 Recently, it has been reported that the compound ciglitazone induces EGR‐1 and leads to inhibition of lung cancer cell proliferation.33 In this study, we observed that TCM YYJD induces proliferation inhibition and apoptosis in lung cancer cells (Figure 1A). This evidence concerns the gene EGR1 and lung cancer.