Fyn requires the microtubule-associated protein Tau, a protein that is implicated in neurodegenerative diseases including Alzheimer's disease (AD) and frontotemporal dementia (FTD), for its efficient targeting to the dendritic compartment (Ittner et al., 2010; Xia et al., 2015). The gene discussed is FYN; the disease is early-onset autosomal dominant Alzheimer disease.