Further, increased Tau expression (in particular that of mutant Tau forms found in FTD, such as P301L Tau) is associated with increased synaptic localization, not only of Tau but also of Fyn (Ittner et al., 2010; Xia et al., 2015; Hoover et al., 2010). This evidence concerns the gene MAPT and frontotemporal dementia.