This has also been shown for Tau carrying the P301L mutation found in familial cases of FTD, which mislocalizes to dendritic spines (Xia et al., 2015; Hoover et al., 2010) and has an increased affinity towards Fyn in vitro (Bhaskar et al., 2005). The gene discussed is MAPT; the disease is frontotemporal dementia.