The results confirmed that combination use of CEA‐CAR‐T cells and rhIL‐12 showed significantly enhanced anti‐tumor activity against in vivo growth of colorectal cancer cell HT‐29, pancreatic cancer cell AsPC‐1 and gastric cancer cell MGC803 than single use of CEA‐CAR‐T cells. This evidence concerns the gene CEACAM5 and colorectal cancer.