As shown in Figure 5B, in mice injected with CEA‐positive HT‐29‐RFP, AsPC‐1‐RFP, or MGC803‐RFP tumor cells and thereafter injected with CEA‐CAR‐T cells, the levels of serum cytokines were significantly increased compared with control‐T cell or control‐T cell in combination with rhIL‐12 treatment mice. This evidence concerns the gene CEACAM5 and neoplasm.