CEA has been found to be expressed on several types of cancer, for example, colorectal cancer, pancreatic cancer, gastric cancer, lung cancer, breast cancer, and its expression is correlated with the degree of cancer malignancy.20 Therefore, we designed CEA‐specific CAR‐T cells and evaluated their efficacy in solid tumor treatment when in combination use with rhIL‐12. This evidence concerns the gene CEACAM5 and colorectal cancer.