The results confirmed that combination use of CEA‐CAR‐T cells and rhIL‐12 showed significantly enhanced anti‐tumor activity against in vivo growth of colorectal cancer cell HT‐29, pancreatic cancer cell AsPC‐1 and gastric cancer cell MGC803 than single use of CEA‐CAR‐T cells. Here, CEACAM5 is linked to neoplasm.