SIRT3 and acute myeloid leukemia: Given that sophisticated regulation of ROS production is required for the maintenance of leukaemic blasts and stem cells, we investigated the regulatory mechanism of mitochondrial ROS in chemoresistance of AML, which may not only contribute to a better understanding of SIRT3 in haematopoietic malignancies, but also provide the rationale of targeting SIRT3 to improve chemotherapy outcome.