IDH2 and acute myeloid leukemia: For example, an IDH2 mutant found in AML plays an essential role in the epigenetic changes via its oncogenic metabolite, 2‐hydroxyglutarate, that has critical impact on epigenetic changes in AML, as well as its capability to alter the mitochondrial ROS production via NADPH and GSH (Jo et al, 2001; Lee et al, 2003; Ward et al, 2010).