To confirm that ROS is the key mechanism that SIRT3 utilises to regulate AML cell death upon drug treatment, MV4‐11 cells were exposed to PTL, a well‐known ROS inducer that displays selective toxicity to both leukaemic blasts and stem cells via ROS induction (Guzman et al, 2005). The gene discussed is SIRT3; the disease is acute myeloid leukemia.