In addition to TMB and antigen presentation-related parameters, the model identified a set of prior to therapy observables such as CD8 T cell clonality in blood or abundance of Teff and Treg and their ratio in the tumor, as well as parameters such as the density of naïve T cell in the blood, number of TdLNs, and T cell killing rate as important markers for higher chance of tumor shrinkage. Here, CD8A is linked to neoplasm.