CD274 and non-small cell lung carcinoma: In particular, approved antibodies against PD-1 (nivolumab (2–4) and pembrolizumab (5–7)), PD-L1 (atezolizumab (8) and durvalumab (9)), and combination of nivolumab and anti-CTLA-4 (ipilimumab) (10) have significantly improved the overall survival of the advanced NSCLC patients.