CD8 T cell clonality could be measured by TCR-sequencing of the CD8 T cells in patient’s blood, although it is not trivial to identify the tumor-specific clones unless by in vitro examination of T cell expansion in response to patient antigen (28,38), or probabilistic estimation using sequence similarity of antigen to foreign epitopes identified in the Immune Epitope Database (IEDB) (39). Here, CD8A is linked to neoplasm.