As previously discussed, overexpression of Mcl-1 in AML is often synonymous with disease relapses and the ability of flavopiridol to repress the expression of Mcl-1 is believed to contribute to the synergism found in the FLAM regimen by potentiating the activities of cytarabine and mitoxantrone (119). Here, MCL1 is linked to acute myeloid leukemia.