TP53 and carcinoma: The two polymorphisms found in the encoded TP53 and KIT (NM_000546.5: c.215C> G, TP53; NM_000222.2: c.1621A> C, KIT) imply that the carcinoma developed from the biliary adenofibroma since it is not a “true” mutation in the sequence-specific DNA-binding domain of the TP53 tumor suppressor gene between amino acids 102–292 [21].