In conclusion, BAY 94-9027 had an extended t1⁄2, a higher AUC (based on direct measurement), and longer median time to > 1 IU/dL FVIII (based on popPK modeling) compared with rFVIIIFc following a single infusion in patients with severe hemophilia A. Real-world data may provide an insight into whether these PK advantages provide additional bleeding protection. Here, F8 is linked to hemophilia A.