This IPD meta-analysis found that, per 1 SD increase in Lp-PLA 2 mass, there was increased ischemic stroke risk (RR 1.14; 95% CI 1.02–1.27), and per 1 SD increase in LpPLA2 activity, there was significantly increased CHD risk (RR 1.10, 95% CI 1.05–1.16). This evidence concerns the gene PLA2G7 and ischemic stroke.