AGTR1 and heart disorder: Therefore, the salient therapeutic implication of this physiological role of adrenal βarrestin1 is that a drug targeting the AT1R (such an ARB‐angiotensin receptor blocker, an AT1R antagonist) needs to block both the G protein– and the βarrestin1–dependent pathways equally well in the adrenals, in order to effectively suppress aldosterone production and lower its blood levels, which would also help ameliorate tobacco–related heart disease.