In 2016, HK Cho et al. examined the dorsal root ganglion tissues of the lumbar disc herniation rats and found that the group that was treated with 300mg of Shinbaro showed downregulated neuroglial activity, as well as decreased expressions of CGRP and transient receptor potential cation channel subfamily V member 1 (TRPV1), compared to the aceclofenac treated group or to a vehicle control group [14]. Here, TRPV1 is linked to lumbar disc herniation.