22 Type II SCV is characterized by monoclonal and polyclonal IgM and IgG and is linked with infectious diseases, such as hepatitis C. 22,23 Type III SCV is characterized by polyclonal IgM and IgG and is associated with inflammatory diseases such as ulcerative colitis and Crohn’s disease. 3,24. This evidence concerns the gene CD40LG and ulcerative colitis.