Considering that SYNE1, the gene most likely affected by rs9371601, is a large gene containing many exons and undergoes extensive alternative splicing processes (Additional file 6: Figure S1), further studies analyzing the association between rs9371601 and mRNA levels of different transcripts of SYNE1 are necessary, given that accumulating studies have proven the important roles of alternative splicing in the pathogenesis of psychiatric disorders [44, 46, 47]. This evidence concerns the gene SYNE1 and psychiatric disorder.