TLR4 and hereditary angioedema: Relative mRNA expression analyses showed increased CD274 (1.69 vs. 1.01, p = 0.038), IL1B (9.32 vs. 0.95, p = 0.0008), IL1RN (11.05 vs. 0.65, p = 0.0001), IL8 (2.94 vs. 0.78, p < 0.0001), MMP9 (3.33 vs. 0.45, p < 0.0001), and TLR4 (2.62 vs. 0.96, p = 0.0012) levels in HAE patients than in HD (Figure 2).