There was a significant increase in CD11b MFI (19.89 vs. 15.45, p = 0.0071) and a decrease in CD16 MFI (218.7 vs. 183; p = 0.0443) in HAE patients compared to HD (Figure 3, Fig.  S3), which supported neutrophil activation in HAE patients. This evidence concerns the gene ITGAM and hereditary angioedema.