CD274 and hereditary angioedema: A significant increase in the relative CD274+ neutrophils count (0.79 % vs. 0.16 %, p = 0.0016) and CD87+ neutrophils (6.82 % vs. 0.91 %, p < 0.0001) in HAE patients compared to HD (Figure 4) further indicated neutrophil alertness in HAE patients.