Its role is to facilitate RHO GTPase to the GDP state and consequently to induce the cellular motility.2 These types of translocations are common in diffuse GC and have been demonstrated to be negative prognostic factors.30–33 Of note, Tanaka and colleagues demonstrated that cases with CLDN18 translocation are significantly characterised by a CLDN18 IHC overexpression.32 This evidence concerns the gene CLDN18 and gastric cancer.