SOCS2 and chronic myelogenous leukemia, BCR-ABL1 positive: As for hematopoietic malignancies, SOCS2 expression was significantly increased in patients with chronic myeloid leukemia (CML) in blast crisis as compared to chronic phase patients and healthy controls28, but its absence did not alter the latency or histopathologic features of CML like disease in mice transplanted with BCR-ABL1 transduced bone marrow cells26.