Consistent with a role for LUM in cardiac remodeling and failure, Ingenuity pathway analysis (IPA) of DE transcripts identified 11 cardiotoxicity pathways including “cardiac infarction”, “congenital heart anomaly”, “cardiac hypertrophy”, “cardiac dysfunction”, “cardiac necrosis/cell death”,”cardiac fibrosis”, “cardiac congestive/cardiac failure/heart failure”, “cardiac arrhythmia”, “cardiac output”, “cardiac enlargement” and “cardiac inflammation” (Table S4), consistent with our in vivo cardiac phenotype. This evidence concerns the gene LUM and chronic obstructive pulmonary disease.