Despite the differences in phenotype observed on echocardiography and heart and lung weights, the expression of signature heart failure markers ANP, BNP, growth differentiation factor GDF15 and ratio of hypertrophic molecules MYH7/MYH6 were not different in LUMKO and WT hearts 2 and 12 weeks post-AB (Fig. S2A–D, respectively). Here, GDF15 is linked to heart failure.