To examine the importance of PPP1R3A to cardiomyocyte hypertrophy across cardiomyopathic etiologies, we also examined its importance in a cardiomyopathy pathway (hypertrophic cardiomyopathy, KEGG), and found that its differential connectivity to this pathway (Fig. 3d) exceeded even that of MYH7 (Fig. 3e), an exemplar cardiomyopathy gene. Here, PPP1R3A is linked to cardiomyopathy.