Compared to the nonfailing network (gray typeface), the failing heart network (red typeface) saw a general rewiring in connectivity within and between these modules; metabolic genes gained a few specific genes such as the protein phosphatase 1 catalytic and regulatory subunits (PPP1CC, PPP1R1A, and PPP1R3A/B/C) and the muscle 6-phosphofructokinase PFKM in the HF network (Fig. 1b, blue). The gene discussed is PPP1CC; the disease is hydrops fetalis.