This effect was associated with unchanged levels of the HF markers Nppa and Nppb in the LV of Ppp1r3a−/− TAC vs. sham mice compared to the expected TAC-induced increase observed in Ppp1r3a+/+mice (Fig. 5b, Nppa: p = 0.006 (ANOVA), Nppb: p = 0.008 (ANOVA)). The gene discussed is NPPA; the disease is hydrops fetalis.