PPP1R3A and hypertrophic cardiomyopathy: To examine the importance of PPP1R3A to cardiomyocyte hypertrophy across cardiomyopathic etiologies, we also examined its importance in a cardiomyopathy pathway (hypertrophic cardiomyopathy, KEGG), and found that its differential connectivity to this pathway (Fig. 3d) exceeded even that of MYH7 (Fig. 3e), an exemplar cardiomyopathy gene.