TRPV4 and squamous cell carcinoma: Fusi et al. detected the expression of TRPV4 by immunohistochemical assay and found that the TRPV4 in weakly metastatic squamous cell carcinoma and basal cell epithelial cancer were significantly lower than that of normal skin tissue, whereas the expression in strongly metastatic malignant melanoma was higher than that of normal tissue89.