Using the specific antagonist HC-067047 to inhibit TRPV4 in hepatocellular carcinoma cells suppressed cell proliferation, induced apoptosis, and decreased the migration capability by attenuating the EMT process in vitro and intraperitoneal injection of HC-067047 could obviously suppress tumor growth in NOD-SCID mouse xenograft models106. The gene discussed is TRPV4; the disease is neoplasm.