TRPV4 and melanoma: GSK1016790A can cause strong calcium-overload and cellular disarrangement, increased the rate of apoptosis, and strongly inhibited human melanoma cell lines (A375, SK-MEL-28, MKTBR) proliferation/survival, similarly in HaCaT keratinocytes90, also in breast cancer cell line MDA-MB-468 pharmacological activation of TRPV4 produced pronounced cell death through apoptosis and oncosis27.