The highest up-regulated lncRNA was lnc-MMP10-3 (absolute FC = 1469.95) among ESCC tissues versus paired non-carcinoma tissues and a total of 809 genes (e.g. S100A16, OLFML2B, and CAST) were related to lnc-MMP10-3 as the standard of absolute PCCs value > 0.8. This evidence concerns the gene CAST and esophageal squamous cell carcinoma.