To verify the reliability of the microarray, we randomly selected 8 notably differentially expressed lncRNAs, including upregulated lnc-MMP1–2 (absolute FC = 10.00), lnc-ABCA12-3 (absolute FC = 9.26), lnc-PTPN7-3 (absolute FC = 6.65), lnc-KIAA1244-2 (absolute FC = 6.24), and downregulated lnc-SLC25A24-1 (absolute FC = 12.80), lnc-ARL4A-4 (absolute FC = 12.12), lnc-FBXL2–4 (absolute FC = 6.69), lnc-SNRNP27-1 (absolute FC = 7.05), and used qRT-PCR analysis to verify the microarray results in 53 pairs of ESCC tumor tissues and adjacent normal tissues. This evidence concerns the gene MMP12 and esophageal squamous cell carcinoma.