To investigate the clinicopathological significance of lncRNAs (lnc-MMP1-2, lnc-ABCA12-3, lnc-PTPN7-3, lnc-KIAA1244-2, lnc-SLC25A24-1, lnc-ARL4A-4, lnc-FBXL2–4 and lnc-SNRNP27-1) expressions in ESCC patients, the patients were classified by sex, age, smoking index, drinking index, differentiation, TNM stages, and clinical stage based on the median expression level of analyzed lncRNAs. The gene discussed is MMP12; the disease is esophageal squamous cell carcinoma.