Recent mutational profiling of HNSCC tumors by our group and others indicates that PIK3CA, a component of PI3K, is the most commonly known oncogenic driver in HNSCC; specifically, gain-of-function mutations in PIK3CA (6%–13%), PIK3CA gene overexpression (52%), and PIK3CA amplification (20%)3,4. This evidence concerns the gene PIK3CA and head and neck squamous cell carcinoma.