LORICRIN and Hyperkeratosis: Addition of hIL-36γ resulted in morphological changes consistent with psoriasis in the model with a prominent increase in thickness of the cornified layer (hyperkeratosis) and a concomitant decrease in the granular layer (hypogranulosis) as well as a significant decrease in the terminal differentiation marker loricrin (Fig. 1C; Supplementary Fig. 2).