Plaque psoriasis or psoriasis vulgaris (PV) is a chronic inflammatory skin disease whose initiation is not well understood but is mechanistically driven by the IL-17/IL-23 axis leading to keratinocyte hyper proliferation and resultant acanthosis, formation of characteristic rete ridges in the epidermis and significant immune cell infiltration into the dermis1,2. The gene discussed is IL17A; the disease is psoriasis vulgaris.