IL1RL2 and psoriasis: Recent studies have shown that chronic administration of mouse IL-36α into mouse ear skin leads to a thickening of the ear, epidermal hyperplasia, significant immune cell infiltration and dysregulation of key psoriasis relevant target genes that can be attenuated by pretreatment with an antagonistic mouse IL-36R antibody supportive of a direct role for IL-36 signaling in driving skin inflammation in mice15.