GAS5 was significantly up-regulated in 7 cell lines out of 9 (HA22T/VGH, HepG2, HUH6, ACHN, Caki-1, MCF-7 and HCC 1937) treated with sorafenib compared to cells treated with DMSO only (Fig. 2D–F). Here, GAS5 is linked to hepatocellular carcinoma.