and p.Arg575*) in the DDX58 (a.k.a. RIG1), a missense variant (p.Thr438Arg) in the DHX58 and a missense (Met619Val) and stop-gain (p.Glu627*) variants present in the IFIH1 (a.k.a. MDA-5) gene of 2 and 7 MS probands, respectively. The gene discussed is RIGI; the disease is myeloid sarcoma.