In addition, amounts in expression of its receptor (VDR), expression of hydroxylases participating in its activation and metabolism (CYP27B1, CYP24A1), as well as the expression of the alternative receptors, retinoic acid-related orphan receptors α and γ (RORα and RORγ) in tumor tissues can affect the outcome of the disease26–29,31–37. This evidence concerns the gene CYP24A1 and neoplasm.