To fill the gap in our knowledge on vitamin D activity in uveal melanoma, we decided to evaluate the expression pattern of the VDR, CYP27B1 and CYP24A1 hydroxylases and RORα and RORγ in the cells of uveal melanoma, in normal melanocytes and in other normal uveal cells in humans. This evidence concerns the gene CYP27B1 and uveal melanoma.