PDCD10 and cavernous hemangioma: Taking advantage of the ProcrCreERT2-IRES-tdTomato/+/Ccm3f/f mouse model, we have also shown that resident endothelial progenitors can trigger the formation of cavernomas upon deletion of Ccm3. We cannot completely exclude that these cavernoma-initiating cells are recruited systemically, as a bone marrow transplantation is not possible on new-born mice.