Lastly, PDK-1 inhibitor AR-12 or PDK-1 knockdown by siRNA significantly suppressed wound healing as well as inhibited migration and invasion of RA-FLS (Fig. 5f–h), which implied that artesunate inhibited RA-FLS migration and invasion through blocking PDK-1 and its downstream pathways. This evidence concerns the gene PDK1 and rheumatoid arthritis.