CENPB and systemic sclerosis: Stimulation with anti-Cenp-B and anti-Topo-I IgGs and with anti-Cenp-B+ and anti-Topo-I+ sera statistically increased all the profibrotic markers compared to control IgGs, to control sera and to SSc sera negative for anti-Cenp-B and anti-Topo-I antibodies and for other ENAs.