Tissue inhibitor of metalloproteinase-1 (TIMP-1), known to promote myocardial fibrosis [36, 37], was also significantly upregulated at the third week compared to its control at the same time and compared to the 1st week of treatment, consistently with the significant upregulation of the related collagen-isoform genes. This evidence concerns the gene TIMP1 and Myocardial fibrosis.