CRHR1 and Anxiety: Evidence shows that CRF/CRFR1 signaling mainly contributes to CRF-induced activation of the CRF-ACTH-CORT axis during the stress response [43], and amygdaloid CRFR1, but not CRFR2, is responsible for stress- and EtOHW-induced anxiety-like behavior in rodents [39, 44].