CRH and Anxiety: Although there is evidence showing that EtOHW time-dependently augments or blunts the CRF-ACTH-CORT response to stress [33], numerous studies have reported a sensitized CRF-ACTH-CORT response to subsequent stressors, including exposure to open areas or elevated spaces in rodents during a relative early stage of EtOHW, which is closely associated with heightened anxiety [34, 35].