Unlike the NPY system that usually exhibits a decreased activity in the CeA during EtOHW [48], evidence reveals that the NOP transcripts in the CeA are increased in response to both acute restraint stress and EtOHW, and that intra-CeA infusions of N/OFQ reduce stress- and EtOHW-induced anxiety and excessive alcohol drinking in rats via amygdaloid mechanisms [49–51]. Here, NPY is linked to Anxiety.