In the HUNT Study (from 1995 to 1997 to 2006–2008), the 11-year cumulative incidence of any diabetes was around 4.5% among adults (20 ≤ age < 70) using self-report, RPG ≥ 11.1 mmol/L, fasting plasma glucose ≥7 mmol/L, HbAc1 ≥ 6.5% or 2-h 75 g OGTT ≥11.1 mmol/L [31]. This evidence concerns the gene ADCY8 and diabetes mellitus.